Research Articles (2009 - 2000)
INTS3 controls the hSSB1-mediated DNA damage response.
Skaar J., D. Richard, A. Tosci, A. Saraf, E. Bolderson, L. Florens, M. Washburn, K. Khanna, and Pagano M.
βTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.
Dehan E., F. Bassermann, D. Guardavaccaro, G. Vasiliver-Shamis, M. Cohen, K. Lowes, M. Dustin, D. Huang, J. Taunton, and Pagano M.
The Impact of Skp2 Overexpression on Recurrence-Free Survival Following Radical Prostatectomy.
Nguyen P., D. Lin, J. Lei, M. Fiorentino, E. Mueller, M. Weinstein, M. Pagano and M Loda.
The F-box protein Fbxo45 promotes the proteasome-dependent degradation of p73.
Peschiaroli A., F Scialpi, F Bernassola, M. Pagano, and G Melino.
Degradation of cyclin A is regulated by acetylation.
Mateo F., M. Vidal-Laliena, N. Canela, L. Busino, M. Martinez-Balbas, M. Pagano, N. Agell and O. Bachs.
Thrombin induces tumor cell cycle activation and spontaneous growth by downregulation of p27Kip1, in association with the upregulation of Skp2 and mir-222.
Hu L., S. Ibrahim, C. Liu, J. Skaar, M. Pagano, and S. Karpatkin.
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA damage response checkpoint.
Bassermann F., D. Frescas, D. Guardavaccaro, L. Busino, A. Peschiaroli, and Pagano M.
KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state.
Frescas D., D. Guardavaccaro, S.Kuchay, H. Kato,A. Poleshko, V. Basrur, K. Elenitoba-Johnson, R. Katz, and Pagano M.
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.
Abbas T., U. Sivaprasad, K. Terai, V. Amador, M. Pagano, and A Dutta.
Control of chromosome stability by the βTRCP-REST-MAD2 axis.
Guardavaccaro, D. Frescas, N. Dorrello, A. Peschiaroli, A. Multani, T. Cardozo, A. Lasorela, A. Iavarone, S. Chang, E. Hernando, and Pagano M.
APE/Ref-1 makes fine tuning of CD40-induced B cell proliferation.
Merluzzi S., G. Gri, V. Gattei, M. Pagano and C. Pucillo.
The HECT-domain ubiquitin ligase Ureb1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
Zhao X., J. Heng, D. Guardavaccaro, M. Pagano, F. Guillemot, A. Iavarone and A. Lasorela.
Rac1 Accumulates in the Nucleus During the G2 Phase of the Cell Cycle and Promotes Cell Division.
Michaelson D., W. Abidi, D. Guardavaccaro, M. Zhou, I. Ahearn, M. Pagano and M. Phillips.
The histone demethylase JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.
Frescas D., D. Guardavaccaro, F. Bassermann, R. Koyama-Nasu and Pagano M.
SCFFbxl3 Controls the Oscillation of the Circadian Clock by Directing the Degradation of Cryptochrome Proteins.
Busino L., F. Bassermann, A. Maiolica, C Lee, S. Godinho, P. Nolan, G. Draetta and Pagano M.
APC/CCdc20 controls the ubiquitin-mediated degradation of p21 in prometaphase.
Amador V., S. Ge, P.G. Santamaria, D. Guardavaccaro and Pagano M.
The after hours mutant reveals a role for FBXL3 in determining mammalian circadian period.
Godinho S., E. Maywood, L. Shaw, V. Tucci, A. Barnard, L. Busino, M. Pagano, R. Kendall, M. Quwailid, R. Romero, J. O'Neill, J. Chesham, D. Brooker, Z. Lalanne, S. Hastings and P. Nolan.
Constitutive phosphorylation of Aurora-A on Ser51 induces its stabilization and consequent overexpression in cancer.
Kitajima S., Y. Kudo, I. Ogawa, M. Tatsuka, H. Kawai, M. Pagano, T. Takata.
Stimulation of prostate cancer cell proliferation and invasion by the Androgen receptor co-activator ARA70.
Peng Y., C. Li, F. Chen, Z.Wang, M. Ligr, J. Melamed, J. Wei, W. Gerald, M. Pagano, M. Garabdian and P. Lee.
DRE-1, an evolutionarily conserved F-box protein that regulates C. elegans developmental age.
Fielenbach N., D. Guardavaccaro, K. Neubert, T. Chan, D. Li, Q. Feng, H. Hutter, M. Pagano and A. Antebi.
Multisite phosphorylation of Nipa at G2/M involves cyclin B1/Cdk1.
Bassermann F., C. vonKlitzing, A. Illert, S. Munch, S. Morris, M. Pagano, C. Peschel and J. Duyster.
Substrate recognition and ubiquitination of SCFSkp2/Cks1 E3 ligase.
Xu S., M. Abbasian, P. Patel, K. Jensen, C. Lombardo, B. Cathers, W. Xie, F. Mercurio, M. Pagano, D. Giegel and S. Cox.
S6K1- and βTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Dorrello N. V., A. Peschiaroli, D. Guardavaccaro, N. H. Colburn, N. E. Sherman and Pagano M.
SCFβTRCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.
Peschiaroli A., N. V. Dorrello, D. Guardavaccaro, M. Venere, T. Halazonetis, N. Sherman and Pagano M.
A peptidomimetic siRNA transfection reagent for highly effective gene silencing.
Utku Y., E. Dehan, O. Ouerfelli, F. Piano, R. N. Zuckermann, M. Pagano and K. Kirshenbaum.
Skp2 contains a novel cyclin a binding domain that directly protects cyclin A from inhibition by p27.
Ji P., L. Goldin, H. Ren, D. Sun, D Guardavaccaro, M. Pagano and L. Zhu.
Modification of Cul1 regulates its association with proteasomal subunits.
Bloom J., A. Peschiaroli, G. DeMartino and Pagano M..
Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.
Lasorella A., J. Stegmueller, G. Rothschild, D. Guardavaccaro, L. delaTorre, M. Pagano, A Bonni and A. Iavarone.
The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain.
Block K., S. Appikonda, A. Horng-Ru Lin, J. Bloom, M. Pagano, and R. Yew.
Structural basis of the Cks1-dependent recognition of p27Kip1 by the SCFSkp2 ubiquitin ligase.
Hao B., N. Zheng, B. Schulman, G. Wu, J. Miller, M. Pagano, and N. Pavletich.
Involvement of the SCF Complex in the Control of Cdh1 Degradation in S-phase.
Benmamar R. and Pagano M.
An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.
Ji P., H. Jiang, K. Rekhtman, J. Bloom, M. Ichetovkin, M. Pagano and L Zhu.
Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation.
Kitajima S., Y Kudo, I. Ogawa, T. Bashir, M. Kitagawa, M. Miyauchi, M. Pagano and T. Takata.
Role of F-box protein βTrcp1 in mammary gland development and tumorigenesis.
Kudo Y., D. Guardavaccaro, P. Santamaria, R. Nasu, E. Latres, R. Bronson, L. Yamasaki and Pagano M.
Ubiquitin-dependent degradation of p73 is Inhibited by PML.
Bernassola F., P. Salomoni, A. Oberst, C. Di Como, M. Pagano, G. Melino and P. P. Pandolfi.
Role of Polo-like kinase in the degradation of Emi1, a regulator of the Anaphase Promoting Complex/Cyclosome.
Moshe Y., J. Boulaire, M. Pagano and H. Hershko.
Alterations in the expression of the cell cycle regulatory protein Cks1 in colorectal carcinoma.
Shapira M., O. Ben-Izhak, B. Bishara, B. Futerman, I. Minkov, M. Krausz, M. Pagano, and D. Hershko.
Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase.
Bashir T., V. Dorrello, V. Amador, D. Guardavaccaro and Pagano M.
Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.
Bloom J., V. Amador, F. Bartolini, G. DeMartino and Pagano M.
Ubiquitin-mediated degradation of Cdc25A by βTrcp during S phase and in response to DNA damage.
Busino L., M. Donzelli, M. M. Chiesa, D. Guardavaccaro, D. Ganoth, N. V. Dorrello, A. Hershko, M. Pagano and G. Draetta.
Role of the SCFSkp2 ligase in the degradation of p21Cip1 In S phase.
Bornstein G., J. Bloom, D. Sitri, K.I. Nakayama, M. Pagano, and A. Hershko.
Control of meiotic and mitotic progression by the F-box protein βTrcp1 in vivo.
Guardavaccaro D., Y. Kudo, J. Boulaire, M. Barchi, L. Busino, M. Donzelli, F. Margottin, P. Jackson, Yamasaki L. and Pagano M.
Altered expression of p27 and Skp2 proteins in prostate cancer of african-american patients.
Drobnjak M., J. Melamed, T. Taneja, K. Melzer, R. Wieczorek, B. Levinson, A. Zeleniuch, D. Polsky, J. Ferrara, R. Perez-Soler, C. Cordon-Cardo, M. Pagano and I. Osman.
Novel p27 C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions.
McAllister S., M. Becker-Hapak, G. Pintucci, M. Pagano and S. F. Dowdy.
Three different binding sites of Cks1 are required for p27-ubiquitin ligation.
D. Sitri, M. A. Seeliger, T. K. Ko, D. Ganoth, L. S. Itzhaki, M. Pagano and A. Hershko.
Dual Mode of Degradation of Cdc25 A phosphatase.
Donzelli M., M. Squatrito, D. Ganoth, Hershko, A., M. Pagano and G. F. Draetta.
In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.
Piva R., J. Liu, R. Chiarle, A. Podda, M. Pagano, and G. Inghirami.
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.
Signoretti S., L. Dimarcotullio, A. Richardson, S. Ramaswamy, B. Isaac, M. Rue, F. Monti, M. Loda and Pagano M.
Structure of the Cul1-Rbx1-Skp1-F-box-Skp2 SCF Ubiquitin Ligase Complex.
Zheng N., B. Schulman, J. Miller, P. Wang, P. Jeffrey, C. Chu, D. M. Koepp, S. Elledge, M. Pagano, R. Conaway, J. Conaway, J. Harperr and N. Pavletich.
Skp2 expression in non-Hodgking lymphomas inversely correlates with p27 expression and defines cells in S-phase.
Chiarle R., F. Yan, R. Piva, H. Boggino, J, Skolnik, D. Novero, G. Palestro, C. DeWolf, M. Chilosi, M. Pagano, and G. Inghirami.
Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70.
Cheng H., C. Cenciarelli, Z. Shao, M. Vidal, W. Parks, M. Pagano and C. Cheng-Mayer.
p27 cytoplasmic localization is regulated by phosphorylation on serine 10 and is not a prerequisite for its proteolysis.
Rodier G., A. Montagnoli, L. DiMarcotullio, P. Coulombe, G. Draetta, M. Pagano and S. Meloche.
Induction of β-TrCP/Fbw1a by JNK signaling and its role in the activation of NF-kB.
Spiegelman V. S., P. Stavropoulos, E. Latres, M. Pagano, H. Furneaux, T. J. Slaga, and S. Y. Fuchs.
Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression.
Carrano A. C. and Pagano M.
The De-ubiquitinating enzyme Unp interacts with the Retinoblastoma protein.
Desalle L., E. Latres, D. Lin, E. Graner, A. Montagnoli, R. Baker, M. Pagano and M. Loda.
The cell cycle regulatory protein Cks1 is required for the SCFSkp2-mediated ubiquitinylation of p27.
Ganoth D., G. Bornstein, T. K. Ko, B. Larsen, M. Tyers, M. Pagano and A. Hershko.
Role of the F-box protein Skp2 in lymphomagenesis
Latres E., R. Chiarle, B. Schulman, N. Pavletich, A. Pellicer, G. Inghirami and Pagano M.
Inverse relationship between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas.
Hershko D., G. Bornstein, O. Ben-Izhak, A. Carrano, M. Pagano, M. Krausz, and A. Hershko.
Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Schulman B., A.C. Carrano, P. Jeffrey, Z. Bowen, E. Kinnucan, M. Finnin, S. Elledge, W. Harper, M. Pagano and N. Pavletich.
Role of the Cdc25A phosphatase in human breast cancer.
Cangi M., B. Cukor, P. Soung, S. Signoretti, G. Moreira, M. Ranashinge, B. Cady, M. Pagano and M. Loda.
Wnt/b-catenin signaling induces the expression and activity of β-TrCP ubiquitin ligase receptor.
Spiegelman V., T. Slaga, M. Pagano, T. Minamoto, Z. Ronai and S. Y. Fuchs.
Five human genes encoding FBP: Chromosomal mapping and analysis of gross mutations in human tumors.
Chiaur D. S., S. Murthy, C. Cenciarelli, M. Loda, G. Inghirami, W. Parks, D. Demetrick, and Pagano M.
Low expression of p27 and low proliferation index do not correlate in hairy cell leukemia.
Chilosi M., R. Chiarle, M. Lestani, F. Menestrina, L. Montagna, A. Ambrosetti, G. Prolla, G. Pizzolo, C. Doglioni, R. Piva, M. Pagano, and G. Inghirami.
Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma.
Chiarle R., L. Budel, J. Skolnik, G. Frizzera, M. Chilosi, A. Corato, G. Pizzolo, J. Magidson, A. Montagnoli, M. Pagano, B. Maes, C. DeWolf, and G. Inghirami.