Research Articles (2009 - 2000)

INTS3 controls the hSSB1-mediated DNA damage response.

Skaar J., D. Richard, A. Tosci, A. Saraf, E. Bolderson, L. Florens, M. Washburn, K. Khanna, and Pagano M.

J of Cell Biol 187:25-32, 2009.

 

βTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.

Dehan E., F. Bassermann, D. Guardavaccaro, G. Vasiliver-Shamis, M. Cohen, K. Lowes, M. Dustin, D. Huang, J. Taunton, and Pagano M.

Mol Cell 33:109-111, 2009.

 

The Impact of Skp2 Overexpression on Recurrence-Free Survival Following Radical Prostatectomy.

Nguyen P., D. Lin, J. Lei, M. Fiorentino, E. Mueller, M. Weinstein, M. Pagano and M Loda.

Urologic Oncology 29:302-308, 2009.

 

The F-box protein Fbxo45 promotes the proteasome-dependent degradation of p73.

Peschiaroli A., F Scialpi, F Bernassola, M. Pagano, and G Melino.

Oncogene 28:3157-3166, 2009.

 

Degradation of cyclin A is regulated by acetylation.

Mateo F., M. Vidal-Laliena, N. Canela, L. Busino, M. Martinez-Balbas, M. Pagano, N. Agell and O. Bachs.

Oncogene 28:2654-2667, 2009.

 

Thrombin induces tumor cell cycle activation and spontaneous growth by downregulation of p27Kip1, in association with the upregulation of Skp2 and mir-222.

Hu L., S. Ibrahim, C. Liu, J. Skaar, M. Pagano, and S. Karpatkin.

Cancer Research 69:3374-3381, 2009.

 

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA damage response checkpoint.

Bassermann F., D. Frescas, D. Guardavaccaro, L. Busino, A. Peschiaroli, and Pagano M.

Cell 134:256-267, 2008.

 

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state.

Frescas D., D. Guardavaccaro, S.Kuchay, H. Kato,A. Poleshko, V. Basrur, K. Elenitoba-Johnson, R. Katz, and Pagano M.

Cell Cycle 7:3539-3547, 2008.

 

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

Abbas T., U. Sivaprasad, K. Terai, V. Amador, M. Pagano, and A Dutta.

Genes & Development 22:2496-2506, 2008.

 

Control of chromosome stability by the βTRCP-REST-MAD2 axis.

Guardavaccaro, D. Frescas, N. Dorrello, A. Peschiaroli, A. Multani, T. Cardozo, A. Lasorela, A. Iavarone, S. Chang, E. Hernando, and Pagano M.

Nature 452:365-369, 2008.

 

APE/Ref-1 makes fine tuning of CD40-induced B cell proliferation.

Merluzzi S., G. Gri, V. Gattei, M. Pagano and C. Pucillo.

Mol Immunology 45:3731-3739, 2008.

 

The HECT-domain ubiquitin ligase Ureb1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.

Zhao X., J. Heng, D. Guardavaccaro, M. Pagano, F. Guillemot, A. Iavarone and A. Lasorela.

Nature Cell Biol 10:643-653, 2008.

 

Rac1 Accumulates in the Nucleus During the G2 Phase of the Cell Cycle and Promotes Cell Division.

Michaelson D., W. Abidi, D. Guardavaccaro, M. Zhou, I. Ahearn, M. Pagano and M. Phillips.

J of Cell Biology 181:485-496, 2008.

 

The histone demethylase JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.

Frescas D., D. Guardavaccaro, F. Bassermann, R. Koyama-Nasu and Pagano M.

Nature 450:309-313, 2007.

 

SCFFbxl3 Controls the Oscillation of the Circadian Clock by Directing the Degradation of Cryptochrome Proteins.

Busino L., F. Bassermann, A. Maiolica, C Lee, S. Godinho, P. Nolan, G. Draetta and Pagano M.

Science 316:900-904, 2007.

 

APC/CCdc20 controls the ubiquitin-mediated degradation of p21 in prometaphase.

Amador V., S. Ge, P.G. Santamaria, D. Guardavaccaro and Pagano M.

Mol Cell 27:462-473, 2007.

The after hours mutant reveals a role for FBXL3 in determining mammalian circadian period.

Godinho S., E. Maywood, L. Shaw, V. Tucci, A. Barnard, L. Busino, M. Pagano, R. Kendall, M. Quwailid, R. Romero, J. O'Neill, J. Chesham, D. Brooker, Z. Lalanne, S. Hastings and P. Nolan.

Science 316:897-900, 2007.

 

Constitutive phosphorylation of Aurora-A on Ser51 induces its stabilization and consequent overexpression in cancer.

Kitajima S., Y. Kudo, I. Ogawa, M. Tatsuka, H. Kawai, M. Pagano, T. Takata.

Plos One 2:e944-doi:10.1371, 2007.

 

Stimulation of prostate cancer cell proliferation and invasion by the Androgen receptor co-activator ARA70.

Peng Y., C. Li, F. Chen, Z.Wang, M. Ligr, J. Melamed, J. Wei, W. Gerald, M. Pagano, M. Garabdian and P. Lee.

Am J of Path 172:225-235, 2007.

 

DRE-1, an evolutionarily conserved F-box protein that regulates C. elegans developmental age.

Fielenbach N., D. Guardavaccaro, K. Neubert, T. Chan, D. Li, Q. Feng, H. Hutter, M. Pagano and A. Antebi.

Dev Cell 12:443-445, 2007.

 

Multisite phosphorylation of Nipa at G2/M involves cyclin B1/Cdk1.

Bassermann F., C. vonKlitzing, A. Illert, S. Munch, S. Morris, M. Pagano, C. Peschel and J. Duyster.

J of Biological Chemistry 282:15965-15972, 2007.

 

Substrate recognition and ubiquitination of SCFSkp2/Cks1 E3 ligase.

Xu S., M. Abbasian, P. Patel, K. Jensen, C. Lombardo, B. Cathers, W. Xie, F. Mercurio, M. Pagano, D. Giegel and S. Cox.

Journal of Biological Chemistry 282:15462-15470, 2007.

 

S6K1- and βTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.

Dorrello N. V., A. Peschiaroli, D. Guardavaccaro, N. H. Colburn, N. E. Sherman and Pagano M.

Science 314:467-471, 2006.

 

SCFβTRCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.

Peschiaroli A., N. V. Dorrello, D. Guardavaccaro, M. Venere, T. Halazonetis, N. Sherman and Pagano M.

Mol Cell 23:319-329, 2006.

 

A peptidomimetic siRNA transfection reagent for highly effective gene silencing.

Utku Y., E. Dehan, O. Ouerfelli, F. Piano, R. N. Zuckermann, M. Pagano and K. Kirshenbaum.

Mol Biosystems 2:312-317, 2006.

 

Skp2 contains a novel cyclin a binding domain that directly protects cyclin A from inhibition by p27.

Ji P., L. Goldin, H. Ren, D. Sun, D Guardavaccaro, M. Pagano and L. Zhu.

J of Biological Chemistry 281:24058-24069, 2006.

 

Modification of Cul1 regulates its association with proteasomal subunits.

Bloom J., A. Peschiaroli, G. DeMartino and Pagano M..

Cell Div 1:5, 2006.

 

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.

Lasorella A., J. Stegmueller, G. Rothschild, D. Guardavaccaro, L. delaTorre, M. Pagano, A Bonni and A. Iavarone.

Nature 442:471-474, 2006.

 

The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain.

Block K., S. Appikonda, A. Horng-Ru Lin, J. Bloom, M. Pagano, and R. Yew.

Cell Cycle 4:1421-1427, 2005.

 

Structural basis of the Cks1-dependent recognition of p27Kip1 by the SCFSkp2 ubiquitin ligase.

Hao B., N. Zheng, B. Schulman, G. Wu, J. Miller, M. Pagano, and N. Pavletich.

Mol Cell 20:9-19, 2005.

 

Involvement of the SCF Complex in the Control of Cdh1 Degradation in S-phase.

Benmamar R. and Pagano M.

Cell Cycle 4:1230-1232, 2005.

 

An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.

Ji P., H. Jiang, K. Rekhtman, J. Bloom, M. Ichetovkin, M. Pagano and L Zhu.

Mol Cell 16:47-56, 2004.

 

Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation.

Kitajima S., Y Kudo, I. Ogawa, T. Bashir, M. Kitagawa, M. Miyauchi, M. Pagano and T. Takata.

Am J Pathol 165: 2147-2155, 2004.

 

Role of F-box protein βTrcp1 in mammary gland development and tumorigenesis.

Kudo Y., D. Guardavaccaro, P. Santamaria, R. Nasu, E. Latres, R. Bronson, L. Yamasaki and Pagano M.

Mol Cell Biol 24:8184-8194, 2004.

 

Ubiquitin-dependent degradation of p73 is Inhibited by PML.

Bernassola F., P. Salomoni, A. Oberst, C. Di Como, M. Pagano, G. Melino and P. P. Pandolfi.

J Exp Med 99:1545-1557, 2004.

 

Role of Polo-like kinase in the degradation of Emi1, a regulator of the Anaphase Promoting Complex/Cyclosome.

Moshe Y., J. Boulaire, M. Pagano and H. Hershko.

Proc Natl Acad Sci USA 101:7937-7942, 2004.

 

Alterations in the expression of the cell cycle regulatory protein Cks1 in colorectal carcinoma.

Shapira M., O. Ben-Izhak, B. Bishara, B. Futerman, I. Minkov, M. Krausz, M. Pagano, and D. Hershko.

Cancer, 100:1615-21, 2004.

 

Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase.

Bashir T., V. Dorrello, V. Amador, D. Guardavaccaro and Pagano M.

Nature 248:190-193, 2004.

 

Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.

Bloom J., V. Amador, F. Bartolini, G. DeMartino and Pagano M.

Cell 115:71-82, 2003.

 

Ubiquitin-mediated degradation of Cdc25A by βTrcp during S phase and in response to DNA damage.

Busino L., M. Donzelli, M. M. Chiesa, D. Guardavaccaro, D. Ganoth, N. V. Dorrello, A. Hershko, M. Pagano and G. Draetta.

Nature 426: 87-91, 2003.

 

Role of the SCFSkp2 ligase in the degradation of p21Cip1 In S phase.

Bornstein G., J. Bloom, D. Sitri, K.I. Nakayama, M. Pagano, and A. Hershko.

J of Biological Chemistry 278: 25752-25757, 2003.

 

Control of meiotic and mitotic progression by the F-box protein βTrcp1 in vivo.

Guardavaccaro D., Y. Kudo, J. Boulaire, M. Barchi, L. Busino, M. Donzelli, F. Margottin, P. Jackson, Yamasaki L. and Pagano M.

Dev. Cell 4: 799-812, 2003.

 

Altered expression of p27 and Skp2 proteins in prostate cancer of african-american patients.

Drobnjak M., J. Melamed, T. Taneja, K. Melzer, R. Wieczorek, B. Levinson, A. Zeleniuch, D. Polsky, J. Ferrara, R. Perez-Soler, C. Cordon-Cardo, M. Pagano and I. Osman.

Clin. Cancer Research 9:2613-2619, 2003.

 

Novel p27 C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions.

McAllister S., M. Becker-Hapak, G. Pintucci, M. Pagano and S. F. Dowdy.

Mol Cell Biol 23:216-228, 2003.

 

Three different binding sites of Cks1 are required for p27-ubiquitin ligation.

D. Sitri, M. A. Seeliger, T. K. Ko, D. Ganoth, L. S. Itzhaki, M. Pagano and A. Hershko.

J of Biological Chemistry 277:42233-42240, 2002.

 

Dual Mode of Degradation of Cdc25 A phosphatase.

Donzelli M., M. Squatrito, D. Ganoth, Hershko, A., M. Pagano and G. F. Draetta.

EMBO J 21:4875-4884, 2002.

 

In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.

Piva R., J. Liu, R. Chiarle, A. Podda, M. Pagano, and G. Inghirami.

Mol Cell Biol 22:8375-8387, 2002.

 

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.

Signoretti S., L. Dimarcotullio, A. Richardson, S. Ramaswamy, B. Isaac, M. Rue, F. Monti, M. Loda and Pagano M.

J of Clinical Investigation 110:633-641, 2002.

 

Structure of the Cul1-Rbx1-Skp1-F-box-Skp2 SCF Ubiquitin Ligase Complex.

Zheng N., B. Schulman, J. Miller, P. Wang, P. Jeffrey, C. Chu, D. M. Koepp, S. Elledge, M. Pagano, R. Conaway, J. Conaway, J. Harperr and N. Pavletich.

Nature 416:703-709, 2002.

 

Skp2 expression in non-Hodgking lymphomas inversely correlates with p27 expression and defines cells in S-phase.

Chiarle R., F. Yan, R. Piva, H. Boggino, J, Skolnik, D. Novero, G. Palestro, C. DeWolf, M. Chilosi, M. Pagano, and G. Inghirami.

Am J Pathol 160: 1457-1466, 2002.

 

Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70.

Cheng H., C. Cenciarelli, Z. Shao, M. Vidal, W. Parks, M. Pagano and C. Cheng-Mayer.

Current Biology 11: 1771-1775, 2001.

 

p27 cytoplasmic localization is regulated by phosphorylation on serine 10 and is not a prerequisite for its proteolysis.

Rodier G., A. Montagnoli, L. DiMarcotullio, P. Coulombe, G. Draetta, M. Pagano and S. Meloche.

EMBO J 20: 6672-6682, 2001.

 

Induction of β-TrCP/Fbw1a by JNK signaling and its role in the activation of NF-kB.

Spiegelman V. S., P. Stavropoulos, E. Latres, M. Pagano, H. Furneaux, T. J. Slaga, and S. Y. Fuchs.

J of Biological Chemistry 29: 27152-27158, 2001.

 

Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression.

Carrano A. C. and Pagano M.

J of Cell Biology 153: 1381-1389, 2001.

 

The De-ubiquitinating enzyme Unp interacts with the Retinoblastoma protein.

Desalle L., E. Latres, D. Lin, E. Graner, A. Montagnoli, R. Baker, M. Pagano and M. Loda.

Oncogene 20:5538-42 2001.

 

The cell cycle regulatory protein Cks1 is required for the SCFSkp2-mediated ubiquitinylation of p27.

Ganoth D., G. Bornstein, T. K. Ko, B. Larsen, M. Tyers, M. Pagano and A. Hershko.

Nature Cell Biol 3: 321-324, 2001.

 

Role of the F-box protein Skp2 in lymphomagenesis

Latres E., R. Chiarle, B. Schulman, N. Pavletich, A. Pellicer, G. Inghirami and Pagano M.

Proc Natl Acad Sci USA 98: 2515-2520, 2001.

 

Inverse relationship between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas.

Hershko D., G. Bornstein, O. Ben-Izhak, A. Carrano, M. Pagano, M. Krausz, and A. Hershko.

Cancer 91: 1745-1751, 2001.

 

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.

Schulman B., A.C. Carrano, P. Jeffrey, Z. Bowen, E. Kinnucan, M. Finnin, S. Elledge, W. Harper, M. Pagano and N. Pavletich.

Nature 408: 381-386, 2000.

 

Role of the Cdc25A phosphatase in human breast cancer.

Cangi M., B. Cukor, P. Soung, S. Signoretti, G. Moreira, M. Ranashinge, B. Cady, M. Pagano and M. Loda.

J of Clinical Investigation 106: 753-761, 2000.

 

Wnt/b-catenin signaling induces the expression and activity of β-TrCP ubiquitin ligase receptor.

Spiegelman V., T. Slaga, M. Pagano, T. Minamoto, Z. Ronai and S. Y. Fuchs.

Mol Cell 5: 877-882, 2000.

 

Five human genes encoding FBP: Chromosomal mapping and analysis of gross mutations in human tumors.

Chiaur D. S., S. Murthy, C. Cenciarelli, M. Loda, G. Inghirami, W. Parks, D. Demetrick, and Pagano M.

Cytogenetics and Cell Genetics 88: 255-258, 2000.

 

Low expression of p27 and low proliferation index do not correlate in hairy cell leukemia.

Chilosi M., R. Chiarle, M. Lestani, F. Menestrina, L. Montagna, A. Ambrosetti, G. Prolla, G. Pizzolo, C. Doglioni, R. Piva, M. Pagano, and G. Inghirami.

British J of Haematology 111:263-271, 2000.

 

Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma.

Chiarle R., L. Budel, J. Skolnik, G. Frizzera, M. Chilosi, A. Corato, G. Pizzolo, J. Magidson, A. Montagnoli, M. Pagano, B. Maes, C. DeWolf, and G. Inghirami.

Blood 95: 619-626, 2000.