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Research Articles (2019 - 2010)

Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1.

Lignitto L., LeBoeuf S., Homer H., Jiang S., Askenazi M., Karakousi T., Pass H., Bhutkar A., Tsirigos A., Ueberheide B., Sayin V., Papagiannakopulos T, and Pagano M.

Cell 178:316-329, 2019 (See also related PreviewN&V, F1000, and In the News)


Cyclin F controls cell cycle transcriptional outputs by directing the degradation of the three activator E2Fs.

Clijsters L., Hoencamp C., Calis J., Marzio A, Handgraaf S., Cuitino M., Rosenberg B., Leone G., and Pagano M.

Mol Cell 74:1264-1277, 2019.  (See also related N&V, and related review)


GGTase3 is a Newly Identified Geranylgeranyltransferase Targeting a Ubiquitin Ligase.

Kuchay S., Wang H., Marzio A., Jain K., Homer H., Fehrenbacher N., Philpps M., Zheng N., and Pagano M.

Nature Str & Mol Biol, 26:628-636, 2019.  (See also related Editors' Choice and N&V)


Cryptochromes-mediated inhibition of the CRL4-Cop1-complex assembly defines an evolutionary conserved signaling mechanism.

Rizzini L., Levine D., Perelis M., Bass J., Peek C., and Pagano M.

Current Biol 29:1954-1962, 2019.   (See also related Commentary)


Two distinct E2F transcriptional modules drive cell cycles and differentiation.

Cuitino M., Pecot T., Sun D., Kladney R., Okano T., Shinde N., Saeed R., Perez A., Webb A., Liu T., Bae S., Clijsters L., Selner N., Coppola V., Timmers C., Ostrwski C., Pagano M, and Leone G.

Cell Reports 27:3547-3560, 2019.


The F-box domain-dependent activity of EMI1 regulates PARPi sensitivity in triple negative breast cancers.

Marzio A., Puccini J., Kwon Y., Maverakis N., Arbini A., Sung P., Bar-Sagi D., and Pagano M.

Mol Cell 73:224-237, 2019(See also related Preview and F1000)

The ULK1-FBXW5-SEC23B nexus controls autophagy.

Jeong Y., Simoneschi D., Keegan S., Melville D., Adler. N., Saraf A., Florens L., Washburn M., Casavotto C., Fenyo D., Cuervo A., Rossi M., and Pagano M.

eLife 7:e42253, 2018.  (See also related Insight)


NS5A promotes constitutive degradation of IP3R3 to counteract apoptosis induced by hepatitis C virus.

Kuchay S., Saeed M., Giorgi C., Li J., Hoffmann H., Pinton P., Rice C., and Pagano M.

Cell Reports, 25:833-840 2018.


β-TrCP- and Casein Kinase II-mediated degradation of cyclin F controls timely mitotic progression.

Mavrommati I., Faedda R., Galasso G., Li J., Burdova C., Fisher R., Kessler B., Carrero Z., Guardavaccaro D., Pagano M, and D’Angiolella V.

Cell Reports 24:3404-3412, 2018.


PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading.

Rona G., Roberti D., Yin Y., Pagan J., Homer. H., Sassani E., Zeke A., Busino L., Rothenberg E., and Pagano M.

eLife 7:e38771, 2018.


Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L., […] Pagano M., […], and Kroemer G.

Cell Death and Diff, 25:486-541, 2018.

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumor growth.

Kuchay S., Giorgi C., Simoneschi D., Pagan J., Missiroli S., Saraf A., Florens L., Washburn M., Collazo A., Castillo M., Cordon-Cardo C., Sebti S., Pinton P., and Pagano M.

Nature 546:554-558, 2017(See also related News & Views, News & Thoughts, and In the News)


The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells.

Donato V., Bonora, M. Simoneschi D., Sartini D., Kudo Y., Saraf A., Florens L., Washburn M., Stadtfeld M., Pinton, P., and Pagano M.

Nature Cell Biol 19:341-351, 2017(See also related News & Commentary and related Review)


FEM1 proteins are ancient regulators of SLBP degradation.

Dankert J., Pagan J., Starostina N., Kipreos E., and Pagano M.

Cell Cycle 16:556-564, 2017.


GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK.

Pae J., Cinalli R., Marzio, A., Pagano M., and Lehmann R.

Dev Cell 42:130-142, 2017.


Stability of Wake-Sleep Cycles Requires Robust Degradation of the PERIOD Protein.

D'Alessandro M., Beesley S., Kim J., Jones Z., Chen R., Wi J., Kyle K., Vera D., Pagano M., Nowakoski R., and Lee C.

Current Biology 27:3454-3467, 2017.


GPR31 Promotes Membrane Association of KRAS.

Fehrenbacher S., daSilva I., Rairez C., Zhou Y, Cho K., Kuchay S., Shi J., Thomas. S, Pagano M., Hancock J. Bar-Sagi D., and Phillips M.

JCB 216:2329-2338, 2017.


Cyclin F-mediated degradation of SLBP limits H2A.X accumulation and apoptosis upon genotoxic stress in G2.

Dankert J., Rona G., Clijsters L., Geter P., Skaar J., Bermudez K., Sassani E., Fenyo D., Ueberheide B., Schneider R., and Pagano M.

Mol Cell 64:507-519, 2016.  (See also related Review and News & Views)


Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement

and licensing.

Pagan J., Marzio A., Jones M., Saraf A., Jallepalli P., Florens L., Washburn M., and Pagano M.

Nature Cell Biol 17:31-43, 2015.  (See also related News & Views)


TIMELESS forms a complex with PARP1 distinct from its complex with TIPIN and plays a role in the DNA Damage Response.

Young L.M., Marzio A., Perez-Duran P., Reid D., Meredith D., Roberti, D. Star A., Rothenberg E., Ueberheide B., and Pagano M.

Cell Reports 13:451-459, 2015.


The Integrator complexes regulates processing-coupled termination of transcription at diverse classes of gene targets.

Skaar J., Ferris A., Wu X., Saraf A., Khanna K., Florens L., Washburn M., Hughes S. and Pagano M.

Cell Res 25:288-305, 2015. (See also related Mini-Review)


DRE-1/FBXO11 Dependent Degradation of BLMP-1/BLIMP-1 Governs C. elegans Developmental Timing and Maturation.

Horn M.,  Geisen C., Cermak L., Becker B., Nakamura S., Klein C., Pagano M., and Antebi A.

Dev Cell 28: 697-710, 2014.


Cdh1, a substrate-recruiting component of the APC/C ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin.

Choi B., Pagano, M., Huang C., and Dai W.

J of Biological Chemistry 289:17951-17959, 2014.


Plk1 phosphorylates PTEN and regulates its mitotic activity during the cell cycle.

Choi B., Pagano, M., and Dai W.

J of Biological Chemistry 289:14006-14074, 2014.


Fbxo45-mediated degradation of the tumor suppressor Par-4 regulates cancer cell survival.

Chen X., Sahasrabuddhe A., Szankasi P., Chung F., Basrur V., Rangnekar V., Pagano M., Lim M., and Elenitoba-Johnson K.

Cell Death & Diff 21: 1535-1545, 2014.


FBXL2- and PTPL1-mediated and PTPL1-mediated degradation of p85β controls PI3K activity.

Kuchay S., Duan S., Schenkein E., Peschiaroli A., Saraf A., Florens L., Washburn M., and Pagano M.

Nature Cell Biol 15:472-480, 2013.


Regulation of the CRL4Cdt2 ubiquitin ligase and cell cycle exit by the SCFFbxo11 ubiquitin ligase.

Rossi M., Duan S., Jeong Y., Horn M., Saraf A., Florens L., Washburn M., Antebi A., and Pagano M.

Mol Cell 49:1159-1166, 2013.


FBH1 promotes DNA double strand breakage and apopotosis in response to DNA replication stress.

Jeong Y., Rossi M., Cermak L., Saraf A., Florens L., Washburn M., Sung. P, Schildkraut C., and Pagano M.

J of Cell Biol 200:141-149, 2013.


The SCFFbxl3 ubiquitin ligase targets circadian clock Cryptochrome proteins at their open FAD-binding pocket.

Xing W., Busino L., Hinds T., Marionni S., Saifee N., Bush M., Pagano M., and Zheng N.

Nature 496:64-68, 2013.


USP33 regulates centrosome biogenesis through de-ubiquitylation of a centriolar protein, CP110.

Li J., D'Angiolella V., Seeley S., Kobayashi T., Kim S., Pagano M., and Dynlacht B.

Nature 495: 255-259, 2013.


FBH1 is deregulated in melanomas and protects melanocytes from transformation.

Jeong Y., Cermak L., GuiJarro M., Hernando E., and Pagano M.

Cell Cycle 12:1128-1132, 2013.


SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.

Fernández-Sáiz V., Targosz B., Lemeer S., Eichner R., Langer C., Bullinger L., Reiter C., Slotta-Huspenina J., Schroeder S., Knorn A., Kurutz J., Peschel C., Pagano M., Kuster B., and Bassermann F.

Nature Cell Biol 15:72-81, 2013.


Specific small molecule inhibitors of Skp2-mediated p27 degradation.

Wu L., Grigoryan A., Li Y., Hao B., Pagano M., and Cardozo T.

Chemistry and Biology 19:1515-1524, 2012.  (See also related Preview)


Cyclin F-dependent degradation of Ribonucleotide Reductase M2 controls genome stability and DNA repair.

D'Angiolella V., Donato V., Jeong Y., Forrester F., Kudo, Y., Pellacani C., Saraf A., Florens L., Washburn M., and Pagano M.

Cell, 149:1023-1034, 2012.


Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.

Busino L., Millman S., L. Scotto, Kyratsous C., Basrur V., Hoffmann A., O'Connor O., Elenitoba-Johnson K. S., and Pagano M.

Nature Cell Biol, 14:375-385, 2012.


FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.

Duan S., L. Cermak, J. Pagan, M. Rossi, C. Martinengo , P. DiCelle, B. Chapyuy, M. Shipp, R. Chiarle, and Pagano M.

Nature 481:90-93, 2012.


SCFβTrCP-mediated degradation of eEF2K couples protein synthesis elongation to the G2 DNA damage checkpoint.

Kruiswijk F., Yuniati L., Magliozzi R., Bolder R., Lim R., Low T., Heck A., Pagano M., and Guardavaccaro D.

Science Signaling 5:ra40, 2012.


APC/CCdh1 controls the proteasome-mediated degradation of E2F3 during cell cycle exit.

Ping Z., Lim R., Bashir. T., Pagano M., and Guardavaccaro D.

Cell Cycle 11:1999-2005, 2012.


BubR1 is modified by sumoylation during mitotic progression.

Yang F., Hu L., Chen C., Yu J., O’Connell C., Khodjakov A., Pagano M., and Dai W.

J of Biological Chemistry 287:4875-4882, 2012.


Loss of p27kip1 expression in fully staged node negative breast cancer:  Association with lack of hormone receptors in T1a/b, but not T1c infiltrative ductal carcinomas.

Mirchandani D., Ingirani, G., Zeleniuch-Jacquotte A., Cangiarella J., Roses D., Guth A., Safyan R., Formenti S., Pagano M., and Muggia F.

Anticancer Research 31:4401-4406, 2012.


Fbxw7 ubiquitin ligase-meditated degradation of KLF13 prevents RANTES expression in human but not murine T lymphocytes.

Kim D., Zhang W., Millman S., Hwang B., Kwon S., Pagano M., Clayberger C., and Krensky A.

Blood 120:1658-1667, 2012.


Role of RASSF1A in mitosis: regulation of APC/CCdc20 activity by a self-regulatory circuitry.

Chow C., Wong N., Pagano M., Nakayama K., Nakayama K., and Lo K.W.

Oncogene 31:1975-1987, 2012.


mTOR generates an auto-amplification loop by triggering the βTrCP- and Ck1α-dependent degradation of DEPTOR.

Duan S., Skaar J.R., Tosci A., Kanarek N., Ben-Neriah Y., and Pagano M.

Mol Cell 44;317-324, 2011.


The APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.

Cotto-Rios X., Jones M., Busino L., Pagano M., and Huang T.

J of Cell Biology 184:177-186, 2011.


Clinical relevance of Skp2 alterations in metastatic melanoma.

Rose A., Wang G., Hanniford D., Monni S., Tu T., Shapiro R., Berman R., Pavlick A., Pagano M., Darvishian F., Mazumdar M., Hernando E., and Osman I..

Pigment Cell Melanoma Res 24:197-206, 2011.


APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.

Ge S., J. Skaar, and Pagano M.

Cell Cycle 8:167-171, 2011.


SCFCyclin F controls centrosome homeostasis and mitotic fidelity via CP110 degradation.

D’Angiolella, V. Donato, S. Vijayakumar, A. Saraf, L. Florens, M. Washburn, B. Dynlacht, and Pagano M.

Nature 466:138-142, 2010.


Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization.

Bashir T., J. K. Pagan, L Busino, and Pagano M.

Cell Cycle 9: 971-974, 2010.


Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCFβ-TrCP by single substrate depletion.

Kanarek N., E. Horwitz, I. Mayan, M Leshets, G. Cojocaru, M. Davis, B. Tsuberi, E. Pikarsky, M. Pagano, and Y. Ben-Neriah.

Genes & Development 24: 470-477, 2010.

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