Research Articles (Before 2000)

Identification of a family of human F-box proteins.

Cenciarelli C., D. S. Chiaur, D. Guardavaccaro, W. Parks, M. Vidal, and Pagano M.

Current Biology 9: 1177-1179, 1999.

 

Skp2 is required for the ubiquitin-mediated degradation of the Cdk-inhibitor p27.

Carrano A. C., E. Eytan, A. Hershko, and Pagano M.

Nature Cell Biol 1: 193-199, 1999.

 

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.

Montagnoli A., F. Fiore, E. Eytan, A. C. Carrano, G. Draetta, A. Hershko, and Pagano M.

Genes & Development 13: 1181-1189, 1999.

 

The human F-box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of b-catenin.

Latres E., D. S. Chiaur, and Pagano M.

Oncogene 18: 849-854, 1999.

 

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkBa.

Gonen H., B. Bercovich, A. Orian, A. C. Carrano, C. Takizawa, M. Pagano, K. Iwai, and A. Ciechanover.

J of Biological Chemistry 274: 14823-14830, 1999.

 

Downregulation of p27 is associated with development of colorectal adenocarcinoma metastases.

Thomas G., K. Szigeti, M. Murphy, G. Draetta, M. Pagano, and M. Loda.

Am J Pathol 153: 681-687, 1998.

 

Tumor promotion by phorbol ester-induced depletion of protein kinase C is mediated by the ubiquitin-proteasome pathway.

Lu Z., D. Liu, A. Hornia, W. Devonish, M. Pagano, and D. Foster.

Mol Cell Biol 18: 839-845, 1998.

 

Ubiquitin-dependent degradation of Cyclin B1 is accelerated in polyploid megacariocytes.

Zhang Y., Z. Wang, D. Liu, M. Pagano, and K. Ravid.

J of Biological Chemistry 273: 1378-1392, 1998.

 

Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma.

Singh S., J. Lipman, H. Goldman, F. H. Ellis Jr., L. Aizenman, M. G. Cangi, S. Signoretti, D. S. Chiaur, M. Pagano, and M. Loda.

Cancer Research 58: 1730-1735, 1998.

 

Prognostic role of the cell cycle inhibitor p27 in non-small cell lung cancer.

Esposito V., A. Baldi, A. DeLuca, G. Sgaramella, G. Giordano, M. Caputi, M. Pagano, and G. Gordano.

Cancer Research 57: 3381-3385, 1997.

 

Enhanced ribosomal association of p27Kip1 mRNA, a mechanism contributing to accumulation during growth arrest.

Millard S., J. Yan, H. Nguyen, M. Pagano, H. Kiyokawa, and A. Koff.

J of Biological Chemistry 272: 7093-7098, 1997.

 

The cell cycle inhibitor p27 is an independent marker in small (T1a,b) invasive breast carcinomas.

Tan P., B. Cady, M. Wanner, B. Cukon, C. Magi-Galluzzi, P. Lavin, G. Draetta, M. Pagano, and M. Loda.

Cancer Research 57: 1259-1263, 1997.

 

Increased proteasome-dependent degradation of the CDK inhibitor p27 in aggressive colorectal carcinomas.

Loda M., B. Cukon, S. Tam, P. Lavin, M. Fiorentino, G. Draetta, J. Jessup, and Pagano M.

Nature Med 3: 231-234, 1997.

 

Cell cycle regulation of nuclear factor p92 DNA binding activity by novel phase-specific inhibitors.

Grinstein E., I. Weiert, B. Droese, M. Pagano, and H. Royer.

J of Biological Chemistry 271: 9215-9222, 1996.

 

A 39 amino acid fragment of the cell cycle regulator p21 is sufficient to bind PCNA and partially inhibit DNA replication in vivo.

Chen J., R. Peters, P. Saha, P. Lee, A. Theodoras, M. Pagano, G. Wagner, and A. Dutta.

Nucl Acids Res 24: 1727-1733, 1996.

 

Identification of a Myc-dependent step during the assembly of active cyclin/cdk complexes.

Steiner P., A. Philip, J. Lukas, D. Godden, M. Pagano, S. Mittnacht, J. Bartek, and M. Eilers.

EMBO J 14: 4814-4826, 1995.

 

Rescue of defective mitogenic signaling by D-type cyclins.

Roussel M., A. Theodoras, M. Pagano, and C. Sherr.

Proc Natl Acad Sci USA 92: 6837-6841, 1995.

 

Human Cyclin E, a nuclear protein essential for the G1 to S phase transition.

Ohtsubo M., A. Theodoras, J. Schumacher, J. Roberts, and Pagano M.

Mol Cell Biol 15: 2612-2624, 1995.

 

Reconstitution of p53-ubiquitinylation from purified components: the role of human Ubc4 and E6AP.

Rolfe M., P. Romero, S. Glass, I. Berdo, A. Theodoras, M. Pagano, and G. Draetta.

Proc Natl Acad Sci USA 92: 3264-3268, 1995.

 

Role of the Ubiquitin-Proteasome pathway in regulating abundance of the CDK inhibitor p27.

Pagano M., S. Tam, A. Theodoras, P. Beer, S. Delsal, V. Chu, R. Yew, G. Draetta, and M. Rolfe.

Science 269: 682-685, 1995.

 

Differential expression and cell cycle regulation of the Cdk4 inhibitor p16Ink4.

Tam S., J. W. Shay, and Pagano M.

Cancer Research 54: 5816-5820, 1994.

 

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

Tam S., A. Theodoras, J. W. Shay, G. Draetta, and Pagano M.

Oncogene 9: 2663-2674, 1994.

 

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.

Pagano M., Theodoras A. M., Tam S. W., and Draetta G.

Genes & Development 8: 1627-1639, 1994.

 

Modulation of cyclin gene expression by E1A in a cell line with E1A-dependent conditional proliferation.

Spitkovsky D., P. Steiner, J. Lukas, E. Lees, M. Pagano, A. Schulze, S. Joswig, M. Tommasino, M. Eilers, and P. Jansen-Dürr.

J of Virology 68: 2206-2214, 1994.

 

Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumor cell lines.

Lukas J., Pagano M., Z. Staskova, G. Draetta, and J. Bartek.

Oncogene 9: 707-718, 1994.

 

Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells.

Migliacio A., M. Pagano, and F. Aurichio.

Oncogene 8: 2183-2191, 1993.

 

G2 delay induced by nitrogen mustard in human cells affects Cyclin A/Cdk2 and CyclinB/Cdc2 kinase complexes differentially.

O'Connor P., D. Ferris, M. Pagano, G. Draetta, J. Pines, T. Hunter, D. Longo, K. Kohn.

J of Biological Chemistry 268: 8298-8308, 1993.

 

Human Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

Baldin V., J. Lukas, M. J. Marcote, M. Pagano, and G. Draetta.

Genes & Development 7: 812-821, 1993.

 

Differential modulation of cyclin gene expression by myc.

J. Dürr P., A. Meichle, P. Steiner, M. Pagano, K. Finke, J. Botz, J. Wess, G. Draetta, and M. Eilers.

Proc Natl Acad Sci USA 90: 3685-3689, 1993.

 

Regulation of the cell cycle by the Cdk2 protein kinase in cultured human fibroblasts.

Pagano M., R. Pepperkok, J. Lukas, V. Baldin, W. Ansorge, J. Bartek, and G. Draetta.

J of Cell Biology 121: 101- 111, 1993.

 

Binding of the human E2F transcription factor to the retinoblastoma protein but not Cyclin A is abolished in HPV 16-immortalized cells.

Pagano M., M. Dürst, S. Joswig, G. Draetta, and P. Jansen-Dürr.

Oncogene 7: 1681-1686, 1992.

 

Modification of cell cycle controlling nuclear proteins by TGF-ß in HaCaT Keratinocyte cell-line.

Landesman Y., M. Pagano, G. Draetta, V. Rotter, N. Fusenig, and A. Kimchi.

Oncogene 7: 1661-1665, 1992.

 

Cyclin A and Cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extract.

Clarke P., D. Leiss, M. Pagano, and E. Karsenti.

EMBO J 11: 1751-1761, 1992.

 

Inhibition of membrane fusion in vitro via Cyclin B but not Cyclin A.

Thomas L., P. R. Clarke, M. Pagano, and J. Gruenberg.

J of Biological Chemistry 67: 6183-6187, 1992.

 

Cyclin A is required at two points in the human cell cycle.

Pagano M., R. Pepperkok, F. Verde, W. Ansorge, and G. Draetta.

EMBO J 11: 961-972, 1992.

 

Association of Cdk2 kinase with the transcription factor E2F during S phase.

Pagano M., Draetta G., and Jansen-Dürr P.

Science 255: 1144-1147, 1992.