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Pagano M., Latres E. and Chiaur D.S. Ubiquitin ligases as therapeutic targets.

US Patent No. 6,720,181, Australia Patent No. 767507, Japan No. 2000567666, New Zealand Patent No. 510312.


McKenna J., Mercurio F., Plantevin V., Xie W. and Pagano M. Compounds useful for the treatment of cancer, compositions thereof and methods therewith.

U.S. Patent No. 7,037,936.


Pagano M. and Busino, L. Methods to identify compounds useful for tumor sensitization to DNA damage.

US Patent No. 7,439,032.


Pagano M., Peschiaroli, Dorrello, V., A., Skaar J. USP47 inhibitors and methods to induce apoptosis.

U.S. Patent No. 8,037,936.


Pagano M. and Dehan, E. bTrCP1, bTrCP2 and RSK1 or RSK2 inhibitors and methods fo sensitizing target cells to apoptosis.

US Patent No. 8,093,043.


Pagano M. and Bassermann F. Modulating the Cdc14B-Cdh1-Plk1 axis and methods for sensitizing target cells to apoptosis.

US Patent No. 8,076,309.


Pagano M., Peschiaroli A., Lopez-Girona A., Mercurio F. and Xie W. Methods to identify compounds useful for the treatment of proliferative and differentiative disorders.

U.S. Patent No. 8,119,421.


Pagano M., Wu L., Gold L., A., Cardozo T.  Method of treating cancer with modulators of SCFSkp2.

US Patent No. 9,261,497.


Pagano M., Kuchay S., Sebti S.  Geranylgeranyltransferase inhibitor for treatment of a PTEN defective cancer.  Methods of treating a cancer with GGTi-2418 alone or in combination.

US Patent No. 11,583,525.


Pagano M., Dorrello N.V., Vunjak-Novakovic G.  Compositions and methods for treating Alveolar Type II (ATII) cell-dependent lung diseases.

US Patent Application No. 62/715,035.  Pending.


Pagano M., Reynders M., Trauner D.  Photoswitchable PROTACs and Synthesis and Uses Thereof.

US Patent Application No. 62/809,587.   Pending.

Pagano M., Rona G., Zeke A., Miwatani-Minter B.  Methods and compositions for measuring and inhibiting exonuclease activity.

US Patent Application No. 63/130,174.  Pending.

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